- Agents:
- doxorubicin/adriamycin:
- cis platin
- methotrexate:
- Neoadjuvant Chemotherapy:
- may facilitate limb salvage surgery by causing significant necrosis of the primary tumor;
- protocol:
- cis platin: 2 intra-arterial cycles are given at a dose of 120 mg;
- doxorubicin given 20 mg qd for 3 days;
- Musculoskeletal Tumors which are Treated w/ Chemotherapy:
- osteosarcoma
- typically requires 3 cycles of chemotherapy;
- malignant fibrous histiocytoma
- ewing's sarcoma
- typically requires 4 cycles of chemo;
- multiple myeloma:
- Musculoskeletal Tumors which are Not Treated w/ Chemotherapy:
- chondrosarcoma
The effect of chemotherapy on growth in the skeletally immature individual.