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- Dosing:
      - leukemia:
             - 2.5 to 5 mg for children & 2.5 mg to 10 mg for adults;
      - continuous infusion of large amounts of methotrexate may be employed (from 250 mg to 1 g/sq m., q week), when leucovorin rescue is used.
             - supplemental folic acid (1 mg/day) will reduce risk of hematologic
                     toxicity without interfering with efficacy.
- Supplied:
    - scored 2.5 mg tabs and also as a dry powder containing 20 to 250 mg vials;

- Drug Interactions and Toxicity:

Diagnosis and Treatment: Methotrexate in Rheumatoid Arthritis: Indications, Contraindications, Efficacy, and Safety.

Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model.

Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric
    Rheumatology Collaborative Study Group and The Cooperative Children's Study Group

Comparison of auranofin, methotrexate, and the combination of both in the treatment of rheumatoid arthritis. A controlled clinical trial.

Influence of methotrexate and azathioprine on radiologic progression in rheumatoid arthritis. A randomized, double-blind study [see comments]

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