– Discussion: – distal end of femur is hypoplastic, tibia is absent, & proximal dislocation of fibular head; – incidence is 1 in 1 million. – has a familial inheritance; – tibial hemimelia may be terminal or intercalary, complete or incomplete. – 30% percent of … Read more
– Discussion: – type of open bone grafting technique in which wounds are packed w/ cancellous bone w/ no attempt at soft tissue coverage; – may be indicated for infected non unions; – Technique: – for this to be successful the wound must be clean and have adequate blood … Read more
– Discussion: – malposition of the joint line: – varus tibial component positioning – AP and lateral mechanical axias views can often identify subtle malalignment – flexion of femoral component: – will result in loss of full … Read more
– Discussion: – a chronic progressive disease osteoblasts and osteoclasts which results in abnormal bone remodeling; – etiology, staging, and pathogenesis – prevalence: – uncommon in pts under age of 55 yrs but relatively common in later life, occurring in 3-4% of persons over 55 yrs & occurs in 10% in pts over age 80; – reference: – … Read more
– Discussion: – commonly presents in females over age 60 years of age; – pain may or may not be associated w/ acute injury and may be worse at night; – these lesions often show articular degenerative changes, especially when lesions are large or when there is pre-existing varus … Read more
– See: tibial infection and debridement of tibial fractures – Discussion: – see cierny classifcation – a sequestrum is infected dead bone resulting from osteomyelitis; – it is secluded from host immune system and is secluded from antibiotics; – result is a chronic and persistent of infection; … Read more
– Pathogenesis: – see: hematogenous osteomyelitis and pediatric bone circulation – tortuous course of the nutrient vessels in bone causes bacteria to be trapped in the metaphysis; – once lodged in the metaphysis, the infection spreads toward the epiphysis; – in neonates the periosteum … Read more
– Discussion: – predisposing conditions: – open fracture (traumatic tibia infections) – sickle cell anemia – septic arthritis – in children, distinguishing between metaphyseal osteomyelitis and … Read more
(see also: Pyknodyostosis) Discussion: – disease characterized by failure of maturation and organization of collagen fibers; – defect in collagen (procollagen to type I collagen sequence and abnormal cross linking) leading to decreased collagen secretion, bone fragility; – there may be an inability to form normal bone due to a defect in osteoblastic function; – … Read more
– Discussion: – see: homeobox genes database – history: discovered by Marshall Urist in the early 1960s; – currently sixteen different proteins (BMP-1 through BMP-16) have been identified; – these proteins can now be produced by recombinant DNA technology and are further purified by column chromatography; … Read more