The Hip book

Piperacillin / Pipracil

– See:        – Penicillin Family        – AntiPseudomonal Agents – Discussion:     – piperazine penicillin derivative with increased activity against many gm negative bacteria – P.aeruginosa, Enterobacteriacae – S.faecalis; Anaerobes (B.fragilis);     – for serious infect.: 200-300 mg/kg/24hr IV in 4-6 divided doses;     – for complicated … Read more

Phenylbutazone/Butazolidin, Azolid

– Symptomatic treatment of acute gouty arthritis; rheumatoid spondylitis; – musculoskeletal disorders (peritendinitis, bursitis); acute perivascular inflamation; – NSAIA; dosage: 300-600 mg/day in 3-4 divided doses; – should reduce maintenance dose to minimum effective dose (maximum 400mg/day) – Note: erythematous maculopapular rash; – Note: use w/ caution in pts over 40 yrs; ocular and otic … Read more

PHENYLEPHRINE/NEO SYNEPHRINE

– Discussion:  – for treatment of vascular failure in shock, hypersensitivity, or drug induced hypotension; – used to overcome paroxysmal SVT;  – blood pressure maintenance during spinal anesthesia;  – alpha agonist vasoconstrictor:  – Dosage:  – mild hypoTN: 2-5mg IM or SQ elevatesBP for 2 hrs; – 0.1-0.5 mg IV given as slow IV injection;  – … Read more

Phenytoin/Dilantin

– For grand mal and partial seizures; – Adult active siez:18-20mg/kg IV (50mg/min maximum infusion rate); – Oral loading: 15-20mg/kg in doses of 400mg or less at 4 hr intervals; – Maintainance doses: 300-400 mg/24 hr IV/PO divided q12-24 hr, based on plasma values and clinical response; – …or try: Loading dose 750 mg to 1 … Read more

Peptic ulcer disease: Gastritis: PUD

 – H2 blocker:    – Cimetidine        – Zantac            – Pepcid        – Nizatidine  – Other:    – Antacids    – Omerprazole    – Nexium    – Carafate    – Protonix    – Aciphex (rabeprazole sodium):           – proton pump inhibitor approved for … Read more

Penicillamine

– Dose:  – maximum dose for RA patients is 750 mg to 1 g per day; – low doses (125-250 mg) of the drug are used initially with slow-dose titration to reduce the potential for side effects.  – D-penicillamine exhibits similar toxicity profile to IM gold, which includes mucocutaneous reactions, proteinuria, nephrotic syndrome, leukopenia, thrombocytopenia, … Read more

Penicillin G Aqueous

– See: Penicillin Family – DOC for Group A strep, pneumococcus, N. gonorrhea, syphilis; – good for most Gm positive, Streptococcus, Meningitis, Clostridium, Cornybacterium, coliforms, – prophylaxis for bacterial endocarditis;    – Adult: 250-500 mg (400-800 K units) PO qid;    – IV 1.2-24 million units per day; – Strep Pneumonia: 1-2 million units IV q4-6hr; … Read more

PENTAZOCINE/TALWIN

for moderate to severe pain; preop sedation;  Synthetic partial opiate agonist/antagonist;  Dosage:30mg IM or IV; 50-100mg PO q3-4hr prn;  Note that 30-60mg IM equianalgesic to 10mg morphine IM; therefore, use with caution in patients receiving opiate drugs; associated with considerable dysphoria;     KEY SEDATION PAIN OPIOID