Serum CK-MB is useful in diagnosis of acute myocardial infarction after total hip arthroplasty. Surveillance for postoperative MI after noncardiac operations. Effect of early intravenous heparin on coronary patency, infarct size, and bleeding complications after alteplase thrombolysis: results of a randomised double blind European Cooperative Study Group trial. Effects of prophylactic antiarrhythmic drug therapy in … Read more
– See: vascular malformations of the upper extremity – Discussion: – first described by Maurice Raynaud in 1862; – involves vasoconstriction of the cutaneous arteriovenous shunts, digital arteries, and precapillary arterioles; – pallor of the digits with or w/o cyanosis on exposure to cold; – Raynaud’s disease … Read more
– See: Stages of Rheumatoid Arthritis – Discussion: – affects 1-3% of adult population; – female predominance of about 3 to 1; – peak age of onset 35 and 45 years; – most often presents with involvement in the feet and hands (intial involvement occurs in 15% … Read more
– See: – Anti-inflammatory agents – Corticosteroids – Cyclosporin A – Sulfasalazine (anti folate activity) – Remittive Agents: – salicylates – gold – gold salts (inhibit monocyte function) – side effects … Read more
Darvon Pulled From Market by F.D.A. Propoxyphene – Mongabay.com
– Action: – powerful vasodilator and inhibits platelet aggregation thru activation of adenylate cyclase, which leads to an increase in intracellular cyclic adenosine monophosphate; – prostacyclin and thromboxane A(sub 2) are formed from arachidonic acid, w/ endoperoxides & prostaglandins G2 and H2 as intermediates; – variety of drugs with diverse mechanisms … Read more
– for N/V/motion sickness, potentiates narcotics; – adult: 12.5-25mg PO,PR,IM,IV bid/qid; (reduce dose w/ IV and slowly) – drowsiness common; compatable with morphine and meperidine; – motion sickness: 0.5 mg/kg/dose q12hr PO prn; – N/V: 0.25-0.5 mg/kg/dose q4-6hr IM or PR prn; – is a phenothiazine derivative that possesses antihistaminic, sedative, anti-motion sickness, antiemetic and anticholinergic … Read more
– for N/V/Agitation/Antiemetic/Antipyschotic; – Adult: Antiemetic: 5-10 mg PO/IM/IV tid/qid, or 5-10mg deep IM q4-6hr; – Up to 40mg PO q6hr max; 25 mg PR q6-8 hr; – Antipyschotic: 10-20 mg IM acutely or 5-10 mg PO tid/qid for maintainance; – treat extrapyridimal effects with diphenhydramine 25mg in the bag, q6hr; – Contraindications include: comatose … Read more
for anxiety disorders; Benzodiazepine related to chlordiazepoxide; Adult: 5-10mg PO 3 or 4 times qd; 20-50mg PO as single bed time dose to minimize daytime drowsiness; CNS depressant activity may make some activities requiring concentration dangerous for patients (driving); Note that this drug designed for slow conversion to active product, peak: 4-12hr after dose; Note … Read more
– Discussion: – inhibitor of RNA synthesis in osteoclasts; – an effective treatment for hypercalcemia; – given intravenously in a dose of 25 microg per kilogram over a period of four to six hours; – dose can be repeated several times at intervals of 24 to 48 … Read more