The Hip book

Bleeding secondary to Platlet Abnormalities

– Evaulation:  – Patient’s Temperature:  – hypothermia causes platlet dysfunction and increased bleeding time;  – Treatment  – platlets (6-8 units at a time);  – One unit of platlets will increase platlet count by 1000;  – Check 1hr post Platlet Count;  – Dilutional Thrombocytopenia;  – RBC transfusion or IV fluid therapy;  – Treat with Platlet transfusions … Read more

Bite Wounds

 – Discussion: (see: necrotizing fascitis )       – human bite wounds       – snake bite:               –  Bacteriology of rattlesnake venom and implications for therapy.       – cat bite: (see cat scratch disease)              – consider pasteurella multocida;  note P. multocida infection develops within 24hrs;              – with bites on the finger observe for osteomyelitis; … Read more

Benztropine Mesylate/ Cogentin

– for control of extrapyramidal disorders caused by neuroleptic drugs and as an adjunct in the therapy of parkinsonism; – antagonist of acetylcholine, antihistamine; – Parkinsonism:1-2mg PO qd to max dose: 6mg PO qd in 2 divided doses; – initiate low dose:.5mg increments 6 day intervals; – Drug induced extrapyridamal symptoms: 1-4mg qd

Bibliography for osteosarcoma

– Ref Prognostic Features – Ref for Pulmonary Resection in Osteosarcoma – Ref for Surgery & Surgical Limb Salvage – Ref for Radiation Rx for Osteosarcoma – MRI Ref – Chemotherapy Ref Medical Progress: Osteosarcoma: fifteen Years Later. Surgical treatment for osteosarcoma Osteosarcoma of the spine Limb-salvage treatment versus amputation for osteosarcoma of the distal end … Read more

Baclofen

– Discussion:     – is the drug of choice for spasticity;     – it potentiates the inhibitory effect of gamma-aminobutyric acid on reflex arcs;     – adult dosing:            – typical regimen begins with a dose of 5 mg given orally twice a day, which is increased to … Read more

Aztreonam/Azactam

– for aerobic Gm Neg bact and Enteric & P. aeruginosa – Adult: 1-2gm IV/IM q6-12hr; – Not effective for Gm pos nor anaerobic bacteria; – Poor activity with: Staph, enterococci, NonEnteroStrep; – may be given to Penicillin sensative individuals; – Good diffusion from blood into CSF only with inflammation;     Ratio of CSF … Read more

Azathioprine

– Discussion:  – prevents conversion of purine bases by suppressing synthesis of guanine and adenosine; – RA Doses: 1-2.5 mg/kg/day;  – onset of action is usually 12 to 24 weeks;  – discontinuation of the drug is marked by a return in disease activity;  – Toxicity:  – most common toxicity is gastrointestinal including nausea, anorexia, and, … Read more