- often this agent is used on recipient autograft sites or on partial-thickness burn wounds;
- its bacteriostatic properties against both gram-positive and gram- negative organisms (especially pseudomonas aeruginosa) and some anaerobes make it an especially useful agent;
- this agent has the broadest spectrum of activity against pseudomonas organisms in particular and gram negative organisms in general;
- in vitro resistance to pseudomonas has never been demonstrated;
- it is the best agent for treating patients in whom a dense bacterial proliferation in the wound;
- it has limited activity against staphlococcus;
- its application may be painful in partial thickness burns;
- Sulfamylon (mafenide acetate):
- is used either as an 8.5% cream or mixed with saline to form a slurry;
- 11.1% suspension of mafenide acetate, which is bacterostatic, is freely soluble, and readily diffuses through the eschar to establish an effective concentration at the nonviable viable tissue interface;
- as a side effect, metabolic acidosis may develop;
- atopy occurs in approximately 7% of patients treated with mafenide acetate however, this is usually controled with antihistamines
Five percent mafenide acetate solution in the treatment of thermal injuries.
Comparison of silver sulphadiazine 1 per cent, silver sulphadiazine 1 per cent plus chlorhexidine digluconate 0.2 per cent and mafenide acetate 8.5 per cent for topical antibacterial effect in infected full skin thickness rat burn wounds.