- Digoxin metabolism is Inhibited by:
- Erythromycin
- Tetracycline
- quinidine may double Dig levels;
- Verapamil and Amiodarone
- Hypokalemia and HypoMagnesemia and Hypoxia will potentiate toxicity,
- Digoxin bioavailability is decreased by:
- cholestyramine,
- KAOLIN-pectin
- antacids;
- Can cause heart block;
- Toxicity = N/V, diarrhea, HA, GI symptoms, anorexia, pyschiatric, fatique, visual lesions (yellow-green halos around lights) & cardiac arrthymia