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Myasthenic Syndrome (Eaton-Lambert Syndrome)

- Discussion:
    - rare disease usually found in association with occult neoplasms of the lung or other organs;
    - defect lies in the release of acetylcholine from prejunctional axon terminals;
    - main danger to patients is the manifestation of the underlying neoplasm;
- Clinical Findings:
    - fluctuating weakness involving proximal limb girdle;
    - unlike Myasthenia Gravis, weakness is worse on initiating exercise but then subsequently improves w/ exercise;
    - various therapeutic regimens have not helped this disease;
    - muscle weakness tends to be relatively slight