- See: Third Generation Cephalosporin
- Adults: 25 to 150 mg/kg/day IV;
- Peds: 100-150 mg/kg/day q8hr;
- good for Pseudomonas, Gm Neg Eneteric, NonEnterococci Strep; moderate to poor activity against strep; mod to good (85%) against Staph;
- No activity against B.fragilis or enterococci;
- Uncomplicated UTI: 250mg IV/IM q12hr;
- Complicated UTI: 500mg-1gm IV/IM q8-12hr;
- Uncomplicated Pneumoniae and mild skin infections: 500mg-1gm q8hr;
* Bone and joint infections: 2gm IV q12hr;
- Meningitis, serious gyn infections, and intra abdominal infections:
- 2gm IV q8h;
- Psuedomonal lung infections in patients with CF: 30-50mg/kg IV q8hr, up to 6gm/day;
- Usual recomended dosage upto 1gm IV/IM q8-12hr;
- Contra with cephalo allergy, caution with Penicillin allergy;
- Good diffusion from blood into CSFonly with inflammation;
Ratio of CSF to Blood Level (%): Normal Meninges: <1;
InflammedMeninges: 20-40;
- Dosing Regimens for Patients with Renal Insufficiency: (Dose for 70kg Adult{gm/dosing interval in hours}):CrCl: >80:1/8; CrCl:50-79:1/8; CrCl:30-49:1/12; CrCl:10-29:1/24;
- in dialysis patients give a 1 gm supplement dose;
- 75 % of dose will be excreted in urine (w/ nl R F(x))
- Ceftazidime:
- is not as active as the other third-generation cephalosporins against gram-positive cocci, although it is similar to cefotaxime in its activity against the Enterobacteriaceae.
- is most potent of 3rd-generation cephalosporins against Ps.aeruginosa;
- 90 % of strains are susceptible to less/= 8 microgram per milliliter;
- ceftazidime has little activity against most anaerobes