- measurement of the increased rate of settling of erythrocytes is an important laboratory test in evaluation of disease activity in patients with
connective-tissue diseases, certain infections, and neoplastic diseases;
- a useful measure to follow the course of previously diagnosed specific illnesses;
- westergren method;
- normal values are 0-9 mm per hour for men & 0-20 mm/hr for women;
- conditions which increase sed rate:
- orthopaedic Infections
- sed rate in THR
- sed rate: osteomyelitis of the spine
- inflammatory conditions (polymyalgia rheumatica)
- cancer (lymphoma, multiple myeloma)
- pregnancy (third month to 1-month post partum);
- in routine orthopaedic procedures maximum of 25 to 100 mm / hour is reached at 4 days, which gradually decreases to nl over 1-2 weeks;
- w/ more extensive surgery (THR) mild elevation may perist for upto one year;
- heparinized blood;
- conditions that decrease the sed rate:
- rate may be "falsely low" in conditions in which red blood cells do not undergo rouleaux formation;
- sickle cell anemia
- hereditary spherocytosis;
- cold agglutinin disease;
Clinical significance of the erythrocyte sedimentation rate in orthopaedic surgery.
Use of erythrocyte sedimentation rate and C-reactive protein level to diagnose infection before revision total knee arthroplasty. A prospective evaluation.
Original Text by Clifford R. Wheeless, III, MD.
Last updated by Clifford R. Wheeless, III, MD on Sunday, August 11, 2013 10:57 am