- Pts w/ RA:
- may be prone to bacterial infections because of inherent phagocytic defect or because of long-term oral or intraarticular administration of corticosteroid or other immunosuppressive agents;
- staph. aureus is recovered from 80 % infected rheumatoid joints;
Nongonococcal Bacterial Arthritis in Adults Treated at Boston U.Med Center;
-----------------------------------------------------
Type of Bacteria No. of Patients
staphylococcus aureus 39
Streptococcal species 26
- note: patients with strep infections usually have a poor prognosis, and it is important to consider concomitant multiple myeloma;
gram-negative bacilli 22
Diplococcus pneumoniae 6
staphylococcus epidermidis 4
-----------------------------------------------------
- Consider S. aureus (40%), Gr A strep (27%), Enterobacteriaceae (23%);
- Rx: Penase Res Pen (Oxacillin) +/- aminoglycosides
or Timentin or Unasyn
or alternative try vancomycin
Base initial choice on results of gram stain;
Intraarticular antibiotics not required;
Needle drainage perfered except for Hip;
Consider Lyme Disease
* Adult w/ possible VD:
- Consider Gonnorhea; Rx: Ceftriaxone
- Alternative try Spectinomycin or Ciprofloxacin (or if Penase res bug unlikely try Ampicillin;
- Note Gm stain rarely positive;
- Test for genital C.trachomatis; If not available treat empirically