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AMIC / Enhanced Microfracture – Basic Science and Animal Studies

- see human amic studies and perisosteal grafting studies

Biological resurfacing: an alternative to total joint arthroplasty.
            Autogenous meniscus grafts in articular cartilage defects--an experimental study.
Treatment of articular defects with meniscal allografts in a rabbit knee model
[Experimental study on interpositional arthroplasty using collagen membrane]
            Carbon fiber implants in osteochondral defects of the rabbit patella.
Neochondrogenesis in repair of full-thickness articular cartilage defects using free autogenous periosteal grafts in the rabbit. A follow-up in six months
Enhancement of healing in osteochondral defects by collagen sponge implants.
Cross-linked type I and type II collagenous matrices for the repair of full-thickness articular cartilage defects--a study in rabbits.
[Effect of marrow stromal cells derived chondrocytes on repair of full-thickness defects of rabbit articular cartilage]
Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage.
Chondrogenic differentiation capacity of human mesenchymal progenitor cells derived from subchondral cortico-spongious bone.
Effects of calcified cartilage on healing of chondral defects treated with microfracture in horses.
Chondral defect repair after the microfracture procedure: a nonhuman primate model.
Arthroscopic subchondral bone plate microfracture technique augments healing of large chondral defects in the radial carpal bone and medial femoral condyle of horses.
Early events in cartilage repair after subchondral bone microfracture.
Collagen scaffolds for tissue engineering
Chitosan-glycerol phosphate/blood implants increase cell recruitment, transient vascularization and subchondral bone remodeling in drilled cartilage defects
Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects.
            Design of a multiphase osteochondral scaffold. I. Control of chemical composition
Design of a multiphase osteochondral scaffold. II. Fabrication of a mineralized collagen-glycosaminoglycan scaffold
Design of a multiphase osteochondral scaffold III: Fabrication of layered scaffolds with continuous interfaces
Articular Cartilage Resurfacing Using Synthetic Resorbable Scaffolds
Local delivery of autologous platelet in collagen matrix stimulated in-situ.
Biologics in sports medicine: From BMPs to bone formation
Secretary’s Advisory Committee on Xenotransplantation draft reports
Functional Tissue Engineering of Cartilage: Scaffolds and Bioreactors
AAOS Symposia.  Self-Assembling Peptide Hydrogel Scaffolds for Cartilage Tissue EngineeringMajor sections
AAOS Symposia: Design and Optimization of Scaffolds for Cartilage Tissue Engineering
Which stem cell has most chondrogenic potential?
Chondral Lesion Repair in a Goat Model using an Integrated Hydrogel Scaffold and Marrow Stimulation
Treatment of articular cartilage defects in horses with polymer-based cartilage tissue engineering grafts
The effect of porosity and mechanical property of a synthetic polymer scaffold on repair of osteochondral defects
Meniscal repair by fibrocartilage An experimental study in the dog
            Hyaline Cartilage Injuries: Options for Treatment
Orderly osteochondral regeneration in a sheep model using a novel nano-composite multilayered biomaterial
Local Delivery of Autologous Platelet in Collagen Matrix Synergistically Stimulated In-situ Articular Cartilage Repair
In vitro engineering of cartilage
      Repair of articular cartilage defects w/ "2-phase" tissue engineered cartilage constructed by autologous marrow stem cells and "2-phase" allogeneic bone matrix gelatin
            In-situ engineering of cartilage repair: a pre-clinical in-vivo exploration of a novel system.
MR Imaging Protocols for Optimized Visualization of the Collagen Membrane used for Autologous Matrix-induced Chondrogenesis (AMIC®) in Cartilage Repair
            Cartilage repair with chondrocytes in fibrin hydrogel and MPEG polylactide scaffold: an in vivo study in goats
Accelerated and Enhanced Articular Cartilage Regeneration with Nano-Engineered Scaffolds in Microfracture 8288
Local delivery of autologous platelet in collagen matrix stimulated in-situ articular cartilage repair
Formation of cartilage repair tissue in articular cartilage defects pretreated with microfracture and covered with cell-free polymer-based implants
Orthopedic tissue engineering: basic science and practices
A Cell-seeded Implant Scaffold for Articular Cartilage Resurfacing - Stimulating the Body’s Regenerative Powers
            Advancements in Cartilage Regeneration: Microfracture Surgery, Biomaterials and Hydrogels
Matrix-guided cartilage regeneration in chondral defects.
            Bone marrow mesenchymal stem cells in a hyaluronan scaffold for treatment of an osteochondral defect in a rabbit model.
Histological Study of Resection Arthroplasty with and without Tendon Ball Interposition in Dogs
Influence of Scaffold Stiffness on Subchondral Bone and Subsequent Cartilage Regeneration in an Ovine Model of Osteochondral Defect Healing
Chitosan-Glycerol Phosphate/Blood Implants Improve Hyaline Cartilage Repair in Ovine Microfracture Defects
Self-Assembling Peptide Amphiphiles as an Adjunct to Microfracture for Articular Cartilage Regeneration in a Rabbit Model
Novel strategy for chondral lesion repair in a goat model using an integrated hydrogel scaffold and marrow stimulation
Influence of matrix based microfracture for the therapy of chondral defects in a sheep model
Repair of articular cartilage defects in minipigs by microfracture surgery and BMSCs transplantation
Regenerative medecine for cartilage
Repair of articular cartilage defects treated by microfracture and a three-dimensional collagen matrix
Quality of newly formed cartilaginous tissue in defects after transplantation of mesenchymal cells in a composite scaffold based on collagen I with chitosan microfibres.
Healing of canine articular cartilage defects treated with microfracture, a type-II collagen matrix, or cultured autologous chondrocytes.
Cell-Laden and Cell-Free MIC versus microfracture for the Treatment of Articular Cartilage Defects: A Histological and Biomechanical Study in Sheep
Combination of microfracture and periosteal transplantation techniques for the treatment of full-thickness cartilage defects
            Chondrogenic differentiation of human subchondral progenitor cells is impaired by rheumatoid arthritis synovial fluid
Effect of chitosan scaffold microstructure on mesenchymal stem cell chondrogenesis.
Microfracture and bone morphogenetic protein 7 (BMP-7) synergistically stimulate articular cartilage repair.
Matrix guided cartilage regeneration in chondral defects.
Mechanical Response of Porous Scaffolds for Cartilage Engineering
Formation of cartilage repair tissue in articular cartilage defects pretreated with microfracture and covered with cell-free polymer-based implants
Regeneration of ovine articular cartilage defects by cell-free polymer-based implants
Method for improvement of differentiation of mesenchymal stem cells using a double-structured tissue implant
Early posto adherence of matrix-induced ACI for the treatment of full-thickness cartilage defects of the femoral condyle
Novel nano-composite multi-layered biomaterial for the treatment of multifocal degenerative cartilage lesions
Restoring cartilage defects: microfracture to autologous chondrocyte implantation using investigational 3D scaffold
The synergistic effects of microfracture, perforated DBM and adenovirus-bone morphogenetic protein-4 in cartilage defect repair
An in vitro model of biomaterial-augmented microfracture including chondrocyte-progenitor cell interaction.
Degree of differentiation of chondrocytes and their pretreatment with platelet-growth factor. Regulating induction of cartilage formation in resorbable carriers in vivo
Supramolecular design of self-assembling nanofibers for cartilage regeneration.



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