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References by Hunziker


Beta1 integrin deficiency results in multiple abnormalities of the knee joint.
Subcellular distribution of the insulin-like growth factor (IGF) binding proteins (IGFBPs) 2 and 3 in articular chondrocytes.
Surgical suturing of articular cartilage induces osteoarthritis-like changes.
Accelerated hypertrophic chondrocyte kinetics in GDF-7 deficient murine tibial growth plates.
Site-1 protease is essential for endochondral bone formation in mice.
Cartilage histomorphometry.
Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) is closely associated with the chondrocyte nucleus in human articular cartilage.
Chondrogenic differentiation of bovine synovium: bone morphogenetic proteins 2 and 7 and transforming growth factor beta1 induce the formation of different types of cartilaginous tissue.
Translation from research to applications.
Chondrogenic potential of human synovial mesenchymal stem cells in alginate.
Expression of cartilage-related genes in bovine synovial tissue.
The structural architecture of adult mammalian articular cartilage evolves by a synchronized process of tissue resorption and neoformation during postnatal development.
Structural characterization and reliable biomechanical assessment of integrative cartilage repair.
Variation of cell and matrix morphologies in articular cartilage among locations in the adult human knee.
BMP-2 induces the expression of chondrocyte-specific genes in bovine synovium-derived progenitor cells cultured in three-dimensional alginate hydrogel.
Tenomodulin is necessary for tenocyte proliferation and tendon maturation.
Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis.
Bovine primary chondrocyte culture in synthetic matrix metalloproteinase-sensitive poly(ethylene glycol)-based hydrogels as a scaffold for cartilage repair.
Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage.
Stem cell therapy in a caprine model of osteoarthritis.
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.
Role of collagen type II and perlecan in skeletal development.
Mechanical anisotropy of the human knee articular cartilage in compression.
Functional barrier principle for growth-factor-based articular cartilage repair.
Release kinetics of transforming growth factor-beta1 from fibrin clots.
Surgical removal of articular cartilage leads to loss of chondrocytes from cartilage bordering the wound edge.
Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS).
Re: E. B. Hunziker. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis and Cartilage 2002; 10:432-63.
Localization of insulin-like growth factor binding protein-2 in chondrocytes of bovine articular cartilage.
Controlled enzymatic matrix degradation for integrative cartilage repair: effects on viable cell density and proteoglycan deposition.
The mechanosensitivity of cartilage oligomeric matrix protein (COMP).
Quantitative structural organization of normal adult human articular cartilage.
Proteoglycan deposition around chondrocytes in agarose culture: construction of a physical and biological interface for mechanotransduction in cartilage.
Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.
Cartilage oligomeric matrix protein-deficient mice have normal skeletal development.
Importance of the superficial tissue layer for the indentation stiffness of articular cartilage.
Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice.
The role of collagen II and cartilage fibril-associated molecules in skeletal development.
Tissue shear deformation stimulates proteoglycan and protein biosynthesis in bovine cartilage explants.
Structural barrier principle for growth factor-based articular cartilage repair.
Chondrogenesis in cartilage repair is induced by members of the transforming growth factor-beta superfamily.
Immunolocalization of matrix metalloproteinases in partial-thickness defects in pig articular cartilage. A preliminary report.
Development of mechanically stable alginate/chondrocyte constructs: effects of guluronic acid content and matrix synthesis.
Matrix and cell injury due to sub-impact loading of adult bovine articular cartilage explants: effects of strain rate and peak stress.
Delamination rates of tissue flaps used in articular cartilage repair.
Growth-factor-induced healing of partial-thickness defects in adult articular cartilage.
Articular cartilage repair: problems and perspectives.
Differential effects of embryonic immobilization on the development of fibrocartilaginous skeletal elements.
Unconfined compression of articular cartilage: nonlinear behavior and comparison with a fibril-reinforced biphasic model.
Topographical variation of the elastic properties of articular cartilage in the canine knee.
Perlecan maintains the integrity of cartilage and some basement membranes.
Biologic repair of articular cartilage. Defect models in experimental animals and matrix requirements.
Normal skeletal development of mice lacking matrilin 1: redundant function of matrilins in cartilage?
Physical and biological regulation of proteoglycan turnover around chondrocytes in cartilage explants. Implications for tissue degradation and repair.
Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable?
Stimulation of aggrecan synthesis in cartilage explants by cyclic loading is localized to regions of high interstitial fluid flow.
Endochondral ossification is dependent on the mechanical properties of cartilage tissue and on intracellular signals in chondrocytes.
Collagen II is essential for the removal of the notochord and the formation of intervertebral discs.
Effects of injurious compression on matrix turnover around individual cells in calf articular cartilage explants.
Differential effects of IGF-1 and TGF beta-2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes.
Mechanical compression alters proteoglycan deposition and matrix deformation around individual cells in cartilage explants.
Removal of proteoglycans from the surface of defects in articular cartilage transiently enhances coverage by repair cells.
Ultrastructure of adult human articular cartilage matrix after cryotechnical processing.
Chondrocyte biosynthesis correlates with local tissue strain in statically compressed adult articular cartilage.
Optical and mechanical determination of Poisson's ratio of adult bovine humeral articular cartilage.
A new biological glue for cartilage-cartilage interfaces: tissue transglutaminase.
Orthopaedics. Healing of bones, cartilages, tendons, and ligaments: a new era.
Vitrified articular cartilage reveals novel ultra-structural features respecting extracellular matrix architecture.
Evidence for a distinct water-rich layer surrounding collagen fibrils in articular cartilage extracellular matrix.
Adult human chondrocytes cultured in alginate form a matrix similar to native human articular cartilage.
Surface and subsurface morphology of bovine humeral articular cartilage as assessed by atomic force and transmission electron microscopy.
Visualization by magnetic resonance imaging of focal cartilage lesions in the excised mini-pig knee.
Zone-specific cell biosynthetic activity in mature bovine articular cartilage: a new method using confocal microscopic stereology and quantitative autoradiography.
Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane.
A method of quantitative autoradiography for the spatial localization of proteoglycan synthesis rates in cartilage.
Time-dependent changes in the response of cartilage to static compression suggest interstitial pH is not the only signaling mechanism.
Correlation between synthetic activity and glycosaminoglycan concentration in epiphyseal cartilage raises questions about the regulatory role of interstitial pH.
Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture.
Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes.
Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix.
Physiological mechanisms adopted by chondrocytes in regulating longitudinal bone growth in rats.
The role of hypertrophic chondrocytes in endochondral ossification and in the development of secondary centers of ossification.
Quantitation of chondrocyte performance in growth-plate cartilage during longitudinal bone growth
Differential extraction of proteoglycans from cartilage tissue matrix compartments in isotonic buffer salt solutions and commercial tissue-culture media.


Original Text by Clifford R. Wheeless, III, MD.

Last updated by on Friday, January 11, 2013 12:22 pm