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- Discussion:
    - characterized by increased numbers of mast cells in vicera, principally liver, spleen, GI tract, and lymph nodes;
    - skin may show numerous hyperpigmented macules that reflect dermal mast cell accumulation;
    - symptoms of systemic mastocytosis are largely attributable to release of mediator substances from mast cells and include generalized puritis, uticaria, flushing, epsidotic hypotension, peptic ulcer, and syncope;
    - skeletal manifestations include bone pain, tenderness, and deformity due to fracture;

- Radiographs:
    - diffuse poorly demarcated sclerotic and lucent areas that involve axial skeleton


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