- plasma volume expander, for treatment of shock,
- Discussion:
- synthetic colloid with actions similar to Albumin;
- can be safelly used to a total volume of 1.5 liters;
- its available as 6% solution in normal saline w/ osmolarity of 310 mOsm/l;
- it generally provides plasma volume expansion for more than 24 hrs, & like dextran, can be associated w/ urticarial & anaphylactoid reactions;
- half life for 90% of hespan particles is 17 days, whereas that of remaining 10% is 48 days;
- Dosage:
- usually 500-1000ml (do not usually exceed 1500ml/day) IV at a rate not to exeed 20ml/kg/hr;);
- Precautions:
- Not a substitute for blood or plasma;
- Contraindicated in patients with severe bleeding disorders, severe CHF, or renal failure with oliguria or anuria;
- Pentastarch:
- modification of hetastarch;
- has a lower molecular wt and its particle size is more homogeneous;
- half life 2.5 hours;
- rapidly degraded by amylase, & vast majority is cleared in urine by 24 hrs;
- it is available as 10% solution & has greater volume expanding ability than either 5% albumin or 6% hetastarch
The effects of Hespan on serum and lymphatic albumin, globulin, and coagulant protein.