- Discussion:
- uricosuric agent;
- for Gout, maintenance of serum levels of penicillin;
- inhibits tubular secretion of penicillins;
- adult:
- gout: 0.25gm bid for 1 week, then 0.5 gm PO bid;
- penicillin: 1-2 gm PO 30min prior to dose of penicillin;
- Contraindications:
- acute gout (must wait to attack has subsided), caution w/ blood dyscrasias, uric acid kidney stones, h/o PUD;
- avoid concomitant use of penicillin in patients with renal impairment;
- note that salicylates antagonize the uricosuric action of probenecid;
- probenecid may not be effective when the GFR is <30ml/min;
- when probenecid is used for gout, patient should alkalinize urine with Na HCO3 (3--7.5gm qd) and have adequate fluid intake to avoid crystalization of uric acid in acid urine;
- may cause hemolysis in pt w/ G6PD deficiency