- Discussion:
- anti-depression medication:
- is a selective serotonin uptake inhibitor;
- adult: 20mg / 24 hr PO qAM initially; titrate to max dose of 80 mg/24hr;
- note nausea, nervousness, weight loss common;
- note side effects: sedation: +; insomnia: +++; anticholinergic: 0;
- check LFT's; Pt not to have ETOH;
- fluoxetine may dramatically increase tricyclic antidepressant concentration by upto 5 fold;
- increase in concentration of haldol are also seen w/ use of Prozac;
- MAOI combined with fluoxetine may cause development of serotonin syndrome-like illness characterized by anxiety, restlessness, confusion, chills, incoordination, and insomnia;
- combination of fluoxetine and lithium or carbamazepine may also provoke serotonin syndrome