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- For dx of Myasthenia Gravis and serves as a curare antagonist; 
- Anticholinesterase, raises acetylcholine levels; 
- Adults and Peds: 
- Test for Myasthenia: 0.2 mg/kg; give 1/5 dose IV in 1 min; if tolerated, give remainder of dose; positive test is a brief increase in strength; 
- may cause severe cholinergic effects; Keep Atropine available