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- Second Generation Ceph
- Semisynthetic cephalosporin: for surgical prophylaxis:
- 1gm 1hr given preoperatively;
- Severe infections: 2gm qd IV/IM;
- Mild to Moderate infections: 1gm qd IV/IM;
- Uncomplicated UTI: 500mg qd IV/IM;
- Dosing Regimens for Patients with Renal Insufficiency: (Dose for 70kg Adult{gm/dosing interval in hours}):CrCl: >80::1/24;; CrCl:50-79:: 1/24;; CrCl:30-49::1/24;; CrCl:10-29::1/48;;
    - 99 % of dose will be excreted in urine;

 Cefonicid, because of its long half-life of 4.5 hours, has been used successfully in a regimen in which it is administered once a day to treat a variety of mild to moderate infections, including community-acquired pneumonias, urinary tract infections, and infections of the skin and soft tissue

Prophylaxis against infection. Single-dose cefonicid compared with multiple-dose cefamandole.

Duration of preventive antibiotic administration for open extremity fractures.

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