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- for treatment of complicated and uncomplicated UTI due to a

wide variety of pathogens including E. coli

Actinomyces israeli

Amp, PenG

Tetracycline clindamycin
Aeromonas hydrophilia

FQ Norflox

Bacteroides fragilis

Metronidazole clindamycin
Borrelia burgdorferi

Pen G

Enterobacter sp. cloacae,

Proteus mirabilis, indole positive Proteus sp, P. aeruginosa,

Staph aureus, Staphylococcus epidermidis;
- Quinolone antibiotic; inhibits DNA gyrase and inhibits all growth;
- Dosage: 400 mg PO bid 7-10 days (uncomplicated); 10-21 days (complicated);
- impaired renal function (CrCl < 30ml/min) reduce dose to 400mg PO qd;
- Not for use with pediatrics or pregnancy; must be taken 1hr AC or 2hr PC

meals; do not take with antacids;
- Contra w/ hypersensitivity to quinolones;
- Dosing Regimensfor Patients with Renal Insufficiency: - Dose for 70kg

Adult {gm/dosinginterval in hours}: CrCl:>80: 0.4/12;

CrCl:50-79: 0.4/12; CrCl:30-49: 0.4/12; CrCl: 10-29: 0.4/24;

- 30-40% of drug will be excreted in to urine (w/ nl RF(x))
- Norfloxacin will increase levels of Theophylline


Original Text by Clifford R. Wheeless, III, MD.

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