- Discussion:
- for treatment of Candida infections;
- bioavailability of orally administered fluconazole is over 90% compared with intravenous administration
- dose 200 to 400 mg per day
- Cautions:
- Dosing Regimens for Patients w/ Renal Insufficiency:
(Dose for 70 kg Adult (gm/dosing interval in hours) CrCl:>80: 0.1-0.2/24; CrCl: 50-79: 0.1-0.2/24; CrCl: 30-49: 0.05-0.1/24; CrCl:10-29: 0.025-0.05/24;
- 80 % of dose will be excreted in urine (w/ nl R F(x))
- Will falsely incr Serum Cr;
- Will increase effect of warfarin;
- Ratio of CSF to Blood Level (%): Nl Meninges: 70-80; Inflammed: > 70-80
References for Fluconazole:
- A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia. Candidemia Study Group and the National Institute.
- In vitro analysis of antifungal impregnated polymethylmethacrylate bone cement.
- Successful 1-stage exchange total knee arthroplasty for fungal infection.
- Candida arthritis after total knee arthroplasty--a case of successful treatment without prosthesis removal
- Candida albicans prosthetic arthritis treated with fluconazole alone.
- Fungal arthritis--a rare complication of systemic candidiasis or orthopedic intervention. Review of therapeutic experience with fluconazole
- Micafungin plus fluconazole in an infected knee with retained hardware due to Candida albicans.
- Microbiological, clinical, and surgical features of fungal prosthetic joint infections: a multi-institutional experience
- Synovial fluid levels of fluconazole in a patient with Candida parapsilosis prosthetic joint infection who had an excellent clinical response