- Discussion:
    - high grade sarcomas of vascular origin;
    - occur most often in middle aged persons;
    - when the tumor arises in bone, it frequently extends up and down the bone w/ distinctive pattern of "soap bubble" lesions;
    - sub-types:
         - hemangioendothelioma - more common in bone than in soft tissue
         - hemangiopericytoma - more common in soft tissue than in bone;

- Diagnostic Studies:
    - permeative, invasive nature of lesion is evident on CT &  MRI;
    - bone scans show marked radioisotope uptake;

- Histology:
    - fine neoplastic capillaries course thru background of endothelial cells;
    - w/ hemangioendothelioma, pattern is dominated by neoplastic endothelial cells;

- Treatment:
    - angiosarcomas require either a wide surgical margins + adjuvant XRT;
    - radical amputation is also an option

Skeletal-Extraskeletal Angiomatosis. A Clinicopathological Study of Fourteen Patients and Nosologic Considerations.