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Acetaminophren/Tylenol

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  • for mild pain, HA, F, Nonnarcotic analgesic, Antipyretic,
  • Adult: 350-650-1000mg PO q4-6hr; Max: 3.2 gm per 24hr;
  • OD may cause hepatoxicity (often delayed), antidote is N-acetylcystiene;
  • No antiplatlet activity; No antiinflamitory property Caution with patients with Glucose 6 Phos defficiency;
  • Contraindications: Acetominophren hypersensitivity;
  • overdosage presents early as Nausea, Vomiting, and malaise, and presents late as clinical and labratory evidence of hepatotoxicity;
  • Do not use charcol to treat OD;
  • Acetyl-cystein (Muco Myst) may be used depending on the time after ingestion;
  • Supplied: Tabs 325 mg, 500 mg; elixir 120 mg/5 ml; t/2=1-3hrs;
  • Supplied: Caps: 325, 500 mg; tabs: 325, 500, 625;
  • Peds: 10-15 mg/kg/dose PO or PR q4-6hrs;
  • Peds: 0-3mo:  40mg/dose; 4-11mo:  80mg/dose; 12-24mo: 120mg/dose;
    • 4-5yr: 240mg/dose; 6-8yr: 320mg/dose; 9-10yr:  400mg/dose;
    • 11-12yr: 480mg/dose;
  • ACETAMINOPHREN w/ CODEINE (TYLENOL #1,2,3,4);
    • Adult:1-2 tab q3-4hr PRN
    • Codeine content in #1=7.5mg, in #2=15mg, in #3=30mg, in #4=60mg
    • Onset in 30min; Peak in 45-90min;Duration for 4-6hr;t1/2=3-4hr;
    • Peds: Acetaminophen 10 mg/kg/dose; Codeine: 0.5-1.0 mg/kg/dose q4-6hr;
    • Supplied: Tabs, caps

References