- Discussion:
- consists of polyostotic fibrous dysplasia, cafe'-au-lait spots of "coast of Maine" variety, and premature menses;
- it is more common in girls than boys and accompanies approx 1 in 30 cases of polyostotic fibrous dysplasia;
- there is appreciable coincidence of other endocrinologic dz including hyperthyroidism & Cushing's dz as well as
hyperparathyroidism and hypophosphatemic rickets;
- in polyostotic cases of fibrous dysplasia, dx is usually not difficult;
- in monostotic cases, the radiographs are frequently not diagnostic and biopsy may be required;
- malignant transformation is seen in less than 0.5%, with osteogenic sarcoma being the most common neoplasm
- ref: Images in Clinical Medicine. Albright's Hereditary Osteodystrophy
Fibrous dysplasia of the femoral neck. Treatment by cortical bone-grafting.
Images in clinical medicine. Albright's hereditary osteodystrophy.