- Discussion: growth involves either or both of two processes;
- Appositional Growth:
- new cartilage is formed at cartilage surface by cells derived from chondroblasts of perichondrium;
- w/ maturation, majority of cartilage growth is primarily appositional;
- Interstitial Growth:
- increase in internal mass of cartilage by activity of chondrocytes that multiply within their lacunae;
- in mature cartilage, cellular turnover rate is exceedingly low;
- protein polysaccharide undergoes constant synthesis and degraded
Metatropic dwarfism. Uncoupling of endochondral and perichondral growth.