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Bone Remodeling

- See: Essentials in Osteodynamics"

- Discussion:
    - bone remodeling functions reshaping or replacement of of bone during growth and following injury;
           - in the first year of life, almost 100% of the skeleton is replaced;
           - in adults, remodeling procedes at about 10% per year;
    - bone responds to functional demands and muscle attachments;
    - w/ remodeling, bone will be added where needed and removed where it is not required;
    - bone remodeling begins w/ bone resorption, followed by subsequent by bone formation;
           - remodeling process occurs w/ a specific sequence of events termed the Bone multicellular unit (BMU);
    - sequence of events;
           - remodeling may begin w/ parathyroid hormone induced resorption;
           - osteoclastics resorb bone removing both organic and inorganic components are removed;
           - subsequently, new bone by osteoblasts, replacing bone that was resorbed;

- Wolfe's Law:              
    - described by Julius Wolff in 1868.
    - law holds that every change in the form or function of a bone is followed by adaptive changes in its internal architecture and its external shape