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- Discussion:
    - sulfasalazine was developed over 50 years ago to specifically treat RA;
    - more recently it has been found to be efficacious for psoriatic arthritis;
    - typical adult dose is 1 gm per day, but may be increased to 2 gm per day;

- Cautions:
    - most common adverse side effect with sulfasalazine is gastrointestinal intolerance;
    - hematologic toxicity, including hemolytic anemia, folate deficiency, thrombocytopenia, leukopenia, and rarely, aplastic anemia, may occur;
    - rarely, reversible oligospermia, fever, rash, exfoliative dermatitis, and pneumonitis may rarely develop

Sulphasalazine in the management of psoriatic arthritis.

Comparison of sulfasalazine and placebo in the treatment of psoriatic arthritis. A Department of Veterans Affairs Cooperative Study.

Psoriatic arthritis: a quantitative overview of therapeutic options: the Psoriatic Arthritis Meta Analysis Study Group.

Sulphasalazine in psoriatic arthritis: a randomized, multicentre, placebo controled study.