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- onditions include:
- typically involves the axial skeleton;
- affected areas heal w/ fibroblastic proliferation followed by new bone formation;
- pathogenesis of these disorders is unknown except for Reiter's syndrome, which is generally believed to result from aberrant host response to a pathogenic microorganism;
- RF is negative;
- HLA-B27 phenotype:
- typically possitive in seronegative arthritis;
- typically negative in RA;
- Systemic manifestions:
- low grade fever, malaise, wt loss, aortitis.
- look for AR
- iritis assoc seronegative spondyloarthropathies is acute inflammatory process causing redness, pain, and photophobia. (in contrast to JRA it is self limiting and rarely leads to visual impairment.)
- pain at ligament and tendon insertions;
- seen frequently, may occur before back symptoms.
- occurs in: metatarsal heads, plantar fascia, achilles tendon
- less common: tibial tubercle, patella, greater trochanter, iliac crest, sacroiliac joints, and clavicle.